Beta Glucan Complex
Vitamin C, D3, B9, zinc and selenium contribute to normal function of the immune system
A unique product with synergistic effect of the most biologically active (90%) beta-(1,3 / 1,6)-D-glucan, vitamin C, vitamin D, folic acid, selenium, zinc, curcuma root extract and olive leaf extract (oleuropein).
Price: 339,00 kn
Beta glucan is a complex polysaccharide molecule that is most commonly obtained from yeast cells (Saccharomyce scerevisiae) and in nature it can be found in some edible mushrooms (reishi, shiitake, maitake), grains (oats and barley) and certain algae species.
Generally beta glukans boost the first “defense line” of the organism. Namely, their main biological immunomodulatory action is based on stimulation of the activity of inherited immune factors.
Beta Glucan & C3 Complex PLUS is a high quality product that contains:
- The most active beta glucan where glucose is connected with 1,3 and 1,6 connections
- Highly purified component Beta 1,3 / 1,6 D-glucan obtained from yeast cell walls (Saccharomyces cerevisiae)
- Significant amount of Beta 1,3 / 1,6 D-glucan in capsule, according to Novel Food Regulations
Curcumin C3 Complex®
- Patented curcumin that is currently the most clinically tested and highest rated curcumin brand in the market with over 85 scientific publications, including clinical researches
- The only curcumin in the market that has been reviewed and recognized by the US FDA for the GRAS status (Generally Recognized As Safe) process, which includes a detailed overview of safety and toxicity
Dry olive leaf extract (Olea europea L.)
- The olive leaf is an excellent source of polyphenolic, biologically active compounds, including oleuropein – the most active compound from olive leaf from which therapeutic activity is tied to therapeutic activity
- Vitamin C, zinc, vitamin D3, folic acid and selenium
Synergy of olive leaf extracts, curcuma, vitamin C, and its antibacterial effect with beta-glucan and immunomodulatory role of zinc, selenium and vitamin D are beneficial to the body’s recovery and contribute to the normal function of the immune system.
||In 3 capsules:|
|Beta 1,3/1,6-D-glucan, min 90%||900 mg|
|Dry olive extract (Olea europea L.) contains at least 20% oleuropein||600 mg|
|Curcumin, dry extract of turmeric rhizomes (Curcuma longa),standardized
to at least 95% of curcuminoids
|Vitamin C (L-ascorbic acid)||80 mg (100% RDA*)|
|Zinc (Zinc Acetate Dihydrate)||10 mg (100% RDA*)|
|Folic Acid (Pteroylmonoglutamic acid)||200 µg (100% RDA*)|
|Selenium (Sodium selenite)||55 µg (100% RDA*)|
|Vitamin D3 (Cholecalciferol)||5 µg (100% RDA*)|
*RDA – Recommended Daily Allowances
Vitamin C, vitamin D3, folic acid, zinc – contributse to the normal function of the immune system
Vitamin C, folic acid – contributes to fatigue and exhaustion reduction
Vitamin C, Zinc, selenium – contributes to the protection of cells from oxidative stress
Vitamin C – contribute to normal energy metabolism
It is recommended to take 1-2 capsules daily, best during the meal.
Recommended daily doses should not be exceeded. A dietary supplement is not a substitute or replacement for a balanced diet. Keep out of the reach of small children. It is important to adhere to a balanced and varied diet and a healthy lifestyle.
Capsules has neutral taste and smell, 100% from plant sources, also suitable for vegetarians.
People who take drugs should consult a physician. Not recommended for disorders of the digestive system, thyroid disease, pregnant and nursing women.
Store in a dry place, at temperature up to 25ºC.
Rylander, R. Organic dust induced pulmonary disease – the role of mould derived beta-glucan. Ann.Agric.Environ.Med. 2010;17(1):9-13.3
Sable, C. A., Strohmaier, K. M., and Chodakewitz, J. A. Advances in antifungal therapy. Annu.Rev.Med. 2008;59:361-379.
Saito, T., Shime, N., Itoh, K., Fujita, N., Saito, Y., Shinozaki, M., Shibuya, K., Makimura, K., and Hashimoto, S. Disseminated aspergillosis following resolution of Pneumocystis pneumonia with sustained elevation of beta-glucan in an Intensive Care Unit: a case report. Infection 2009;37(6):547-550.
Shimizu, C., Kihara, M., Aoe, S., Araki, S., Ito, K., Hayashi, K., Watari, J., Sakata, Y., and Ikegami, S. Effect of high beta-glucan barley on serum cholesterol concentrations and visceral fat area in Japanese men–a randomized, double-blinded, placebo-controlled trial. Plant Foods Hum.Nutr. 2008;63(1):21-25.
Sier, C. F., Gelderman, K. A., Prins, F. A., and Gorter, A. Beta-glucan enhanced killing of renal cell carcinoma micrometastases by monoclonal antibody G250 directed complement activation. Int.J.Cancer 5-10-2004;109(6):900-908
Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
Theuwissen, E., Plat, J., and Mensink, R. P. Consumption of oat beta-glucan with or without plant stanols did not influence inflammatory markers in hypercholesterolemic subjects. Mol.Nutr.Food Res. 2009;53(3):370-376.
Tsikitis, V. L., Albina, J. E., and Reichner, J. S. Beta-glucan affects leukocyte navigation in a complex chemotactic gradient. Surgery 2004;136(2):384-389.
Weitberg, A. B. A phase I/II trial of beta-(1,3)/(1,6) D-glucan in the treatment of patients with advanced malignancies receiving chemotherapy. J.Exp.Clin.Cancer Res. 2008;27:40.
Wolever, T. M., Tosh, S. M., Gibbs, A. L., Brand-Miller, J., Duncan, A. M., Hart, V., Lamarche, B., Thomson, B. A., Duss, R., and Wood, P. J. Physicochemical properties of oat beta-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial. Am.J.Clin.Nutr. 2010;92(4):723-732.
Xiang, D., Sharma, V. R., Freter, C. E., and Yan, J. Anti-tumor monoclonal antibodies in conjunction with beta-glucans: a novel anti-cancer immunotherapy. Curr.Med.Chem. 2012;19(25):4298-4305.
Yan, J., Allendorf, D. J., Li, B., Yan, R., Hansen, R., and Donev, R. The role of membrane complement regulatory proteins in cancer immunotherapy. Adv.Exp.Med.Biol. 2008;632:159-174.
Yun, C. H., Estrada, A., Van Kessel, A., Park, B. C., and Laarveld, B. Beta-glucan, extracted from oat, enhances disease resistance against bacterial and parasitic infections. FEMS Immunol.Med.Microbiol. 1-21-2003;35(1):67-7
Arinaga S, Karimine N, Takamuku K, et al. Enhanced induction of lymphokine-activated killer activity after lentinan administration in patients with gastric carcinoma. Int J Immunopharmac 1992;14:535-539.
Dellinger EP, Babineau TJ, Bleicher P, et al. Effect of PGG-glucan on the rate of serious postoperative infection or death observed after high-risk gastrointestinal operations. Betafectin Gastrointestinal Study Group. Arch Surg 1999;134:977-83.
Food and Drug Administration.GRAS Notice 000239 for Yeast Beta-Glucan.Fed registr. 2003; 68: 44207-44209. (http://www.accessdata.fda.gov/scripts/fcn/gras_notices/grn000239.pdf)
Vetvička, V., B.P. Thornton, and G.D. Ross. 1996. Solubleb-glucanpolysaccharide binding to the lectin site of neutrophil or natural killer cell com-plement receptor type 3 (CD11b/CD18) generates a primed state of the recep-tor capable of mediating cytotoxicity of iC3b-opsonized target cells. J.Clin.In-vest.98:50–61.
Chan GC, Chan WK, Sze DM. The effects of beta-glucan on human immune and cancer cells. J Hematol Oncol. 2009;2:25
Jesenak M, Majtan J, Rennerova Z, Kyselovic J, Banovcin P, Hrubisko M. Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. Int Immunopharmacol. 2013;15(2):395-9.
Hunter KW, Gault RA, Berner MD. Preparation of microparticulate β-glucan from Saccharomyces cerevisiae for use in immune potentiation.Letters in Applied Microbiology. 2002: 35(4): 267-271.
Nieman DC, Henson DA, McMahon M, Wrieden JL, Davis JM, Murphy EA, Gross SJ, McAnulty LS, Dumke CL. Beta-glucan, immune function, and upper respiratory tract infections in athletes. Med Sci Sports Exerc. 2008;40(8):1463-71.
Lee OH, Lee BY. Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract. Bioresour Technol. 2010 May; 101(10); 3751-4. [PMID: 20106659]
Micol V, Caturla N, Pérez-Fons L, et al. The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV). Antiviral Res. 2005 Jun;66(2-3): 129-36. [PMID: 15869811]
Markin D, Duek L, Berdicevsky I. In vitro antimicrobial activity of olive leaves. Mycoses. 2003 Apr;46(3-4):132-136. [PMID: 12870202]
Ritchason J. Olive Leaf Extract. Salt Lake City, UT: Woodland Publishing Incorporated; 2007
Olive tree (Olea europaea) leaves: potential beneficial effects on human health.El SN, Karakaya S.Nutr Rev. 2009 Nov;67(11):632-8.
Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according to their chemical structure.Servili M, Esposto S, Fabiani R, Urbani S, Taticchi A, Mariucci F, Selvaggini R, Montedoro GF. Inflammopharmacology. 2009 Apr;17(2):76-84
Active components and clinical applications of olive oil. Waterman E, Lockwood B.Altern Med Rev. 2007 Dec;12(4):331-42.
Omar, S., Oleuropein in Olive and its Pharmacological Effects. Sci Pharm. 2010 Apr-Jun; 78(2): 133–154. Published online 2010 Apr 23.
Generally it can be said that beta-1,3/1,6-glucans enhance the first “defense line” of the organism. Namely, their main biological immunomodulatory action is based on stimulation of the activity of inherited immune factors. Macrophage activation is definitely a crucial moment when activating factors of innate non-specific immunity. This activation is achieved by binding of beta-glucan to several specific macrophage receptors.
Activated macrophages have increased ability to detect, recognize, and destroy pathogens.
With stimulation of phagocytosis, beta-glucans have the ability to stimulate hematopoiesis. Enhanced hematopoiesis involves stimulation of leukocyte and platelet production.
- in high cholesterol, diabetes,
- to strengthen immunity,
- in chronic fatigue and body fatigue,
- as therapy for oncological indications,
- in infectious diseases such as infections of the respiratory tract, infections caused by fungi, bacteria, viruses
- strengthening the immune system
- protection against cardiovascular diseases
- antioxidant properties
Scientists mention as many as 126 pathogenic microorganisms that can not withstand the effects of compounds present in olive leaf extract.
Positive! The European Food Safety Authority (EFSA) in its 2011 published paper (EFSA Journal 2011; 9 (4): 2033) confirmed the influence of oleuropein and olive leaf extracts on the prevention of LDL oxidation (low cholesterol lipoprotein ) associated with plaque formation on the blood vessels wall.
Also, olive leaf is one of the few herbal remedies that has been clinically tested for the treatment of hypertension.
At the molecular level, curcuminoides have demonstrated the ability to inhibit the nuclear factor kappa B (NF-kB), the transcriptional factor inducing and the initiator of various inflammations. NF-kB is involved in various chronic diseases and conditions ranging from cardiovascular disease to cancer. Curcuminoids have significant antioxidative, antiviral, antibacterial and anti-inflammatory activity, support a healthy immune system, and inhibit destructive enzymes in joints and tissues (Aggarwal B. et al. (2006), Curcuma: The Genus Curcuma, pp 297-368).