Beta glucan is a complex molecule of polysaccharides most commonly obtained from the cell yeast walls (Saccharomyce scerevisiae), and in nature it can also be found in some edible mushrooms (reishi, chaga, shiitake, maitake), cereals (oats and barley) and certain algae species.
In general, beta glucans strengthen the body’s first “line of defense.”
Beta Glucan Complex is a high quality product containing:
Curcumin C3 Complex
Dry olive leaf extract
• vitamin C, zinc, vitamin D3, folic acid and selenium
Synergy of ingredients of standardized olive leaf extract, turmeric root extract with the most biologically active beta glucan and vitamin C, folic acid, zinc, selenium and vitamin D that contribute to the normal function of the immune system.
Ingredients: beta- (1,3 / 1,6) -D-glucan from yeast Saccharomyces cerevisiae 90%, dry extract of olive leaves (Olea europaea L.) containing at least 20% oleuropein, thickener: hydroxypropyl methyl cellulose (capsule), dry extract rhizome of turmeric (Curcuma longa) containing at least 95% curcuminoids, L-ascorbic acid, zinc acetate dihydrate, anticoagulant: cellulose powder (ARBOCEL® A300) colecalciferol, pteroylmonoglutamic acid, sodium selenite.
In 3 capsules:
Beta 1,3 / 1,6-D-glucan, min. 90%
Dry olive leaf extract (Olea europea L.) contains at least 20% oleuropein
Dry extract of turmeric rhizome (Curcuma longa) with min. 95% curcuminoids
Vitamin C (L-ascorbic acid)
80 mg (100% RDA*)
Zinc (Zinc acetate dihydrate)
10 mg (100% RDA*)
Folic acid (Pteroylmonoglutamic acid) – vitamin B9
200 µg (100% RDA*)
Selenium (Sodium Selenite)
55 µg (100% RDA*)
Vitamin D3 (Cholecalciferol)
5 µg (100% RDA*)
* RDA – recommended daily intake
Vitamin C, vitamin D3, folic acid, zinc, selenium – contribute to the normal function of the immune system
Vitamin C, folic acid – help reduce fatigue and exhaustion
Vitamin C, zinc, selenium – contribute to the protection of cells from oxidative stress
Vitamin C – contributes to the normal metabolism of energy production
It is recommended to take 1 to 3 capsules a day, preferably half an hour before meals.
The recommended daily doses should not be exceeded. A dietary supplement is not a substitute or replacement for a balanced diet. Keep out of reach of small children. It is important to adhere to a balanced and varied diet and a healthy lifestyle. The capsules have a neutral taste and smell, 100% from a plant source, and are also suitable for vegetarians.
People taking medication should consult a doctor before taking it.
Not recommended for pregnant and breastfeeding women.
In a dry and dark place at a temperature up to 25 ° C.
Rylander, R. Organic dust induced pulmonary disease – the role of mold derived beta-glucan. Ann.Agric.Environ.Med. 2010; 17 (1): 9-13.3
Sable, C. A., Strohmaier, K. M., and Chodakewitz, J. A. Advances in antifungal therapy. Annu.Rev.Med. 2008; 59: 361-379.
Saito, T., Shime, N., Itoh, K., Fujita, N., Saito, Y., Shinozaki, M., Shibuya, K., Makimura, K., and Hashimoto, S. Disseminated aspergillosis following resolution of Pneumocystis pneumonia with sustained elevation of beta-glucan in an Intensive Care Unit: a case report. Infection 2009; 37 (6): 547-550.
Shimizu, C., Kihara, M., Aoe, S., Araki, S., Ito, K., Hayashi, K., Watari, J., Sakata, Y., and Ikegami, S. Effect of high beta- glucan barley on serum cholesterol concentrations and visceral fat area in Japanese men – a randomized, double-blinded, placebo-controlled trial. Plant Foods Hum.Nutr. 2008; 63 (1): 21-25.
Sier, C. F., Gelderman, K. A., Prince, F. A., and Gorter, A. Beta-glucan enhanced killing of renal cell carcinoma micrometastases by monoclonal antibody G250 directed complement activation. Int.J.Cancer 5-10-2004; 109 (6): 900-908
Talbott S, Talbott J. Effect of beta 1,3 / 1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009; 8 (4): 509-515.
Theuwissen, E., Plat, J., and Mensink, R. P. Consumption of oat beta-glucan with or without plant stanols did not influence inflammatory markers in hypercholesterolemic subjects. Mol.Nutr.Food Res. 2009; 53 (3): 370-376.
Tsikitis, V. L., Albina, J. E., and Reichner, J. S. Beta-glucan affects leukocyte navigation in a complex chemotactic gradient. Surgery 2004; 136 (2): 384-389.
Weitberg, A. B. A phase I / II trial of beta- (1,3) / (1,6) D-glucan in the treatment of patients with advanced malignancies receiving chemotherapy. J.Exp.Clin.Cancer Res. 2008; 27:40.
Wolever, TM, Tosh, SM, Gibbs, AL, Brand-Miller, J., Duncan, AM, Hart, V., Lamarche, B., Thomson, BA, Duss, R., and Wood, PJ Physicochemical properties of oat beta-glucan influences its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial. Am.J.Clin.Nutr. 2010; 92 (4): 723-732.
Xiang, D., Sharma, V. R., Freter, C. E., and Yan, J. Anti-tumor monoclonal antibodies in conjunction with beta-glucans: a novel anti-cancer immunotherapy. Curr.Med.Chem. 2012; 19 (25): 4298-4305.
Yan, J., Allendorf, D. J., Li, B., Yan, R., Hansen, R., and Donev, R. The role of membrane complement regulatory proteins in cancer immunotherapy. Adv.Exp.Med.Biol. 2008; 632: 159-174.
Yun, C. H., Estrada, A., Van Kessel, A., Park, B. C., and Laarveld, B. Beta-glucan, extracted from oat, enhances disease resistance against bacterial and parasitic infections. FEMS Immunol.Med.Microbiol. 351 (1): 67-7
Arinaga S, Karimine N, Takamuku K, et al. Enhanced induction of lymphokine-activated killer activity after lentinan administration in patients with gastric carcinoma. Int J Immunopharmac 1992; 14: 535-539.
Dellinger EP, Babineau TJ, Bleicher P, et al. Effect of PGG-glucan on the rate of serious postoperative infection or death observed after high-risk gastrointestinal operations. Betafectin Gastrointestinal Study Group. Arch Surg 1999; 134: 977-83.
Food and Drug Administration.GRAS Notice 000239 for Yeast Beta-Glucan.Fed Registry. 2003; 68: 44207-44209. (http://www.accessdata.fda.gov/scripts/fcn/gras_notices/grn000239.pdf)
Ветвичка, В., Б.П. Thornton, and G.D. Ross. 1996. Solubleb-glucanpolysaccharide binding to the lectin site of neutrophil or natural killer cell com-plement receptor type 3 (CD11b / CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells. J. Clin.In-vest.98: 50–61.
Chan GC, Chan WK, Sze DM. The effects of beta-glucan on human immune and cancer cells. J Hematol Oncol. 2009; 2:25
Jesenak M, Majtan J, Rennerova Z, Kyselovic J, Banovcin P, Hrubisko M. Immunomodulatory effect of pleural (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. Int Immunopharmacol. 2013; 15 (2): 395-9.
Hunter KW, Gault RA, Berner MD. Preparation of microparticulate β-glucan from Saccharomyces cerevisiae for use in immune potentiation.Letters in Applied Microbiology. 2002: 35 (4): 267-271.
Nieman DC, Henson DA, McMahon M, Wrieden JL, Davis JM, Murphy EA, Gross SJ, McAnulty LS, Dumke CL. Beta-glucan, immune function, and upper respiratory tract infections in athletes. With Sci Sports Exerc. 2008; 40 (8): 1463-71.
Lee OH, Lee BY. Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract. Bioresour Technol. 2010 May; 101 (10); 3751-4. [PMID: 20106659]
Micol V, Caturla N, Pérez-Fons L, et al. The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV). Antiviral Res. 2005 Jun; 66 (2-3): 129-36. [PMID: 15869811]
Markin D, Duek L, Berdicevsky I. In vitro antimicrobial activity of olive leaves. Mycoses. 2003 Apr; 46 (3-4): 132-136. [PMID:
Beta-glucans are structural homopolysaccharides from the cell walls of fungi and yeasts, but also cereals (oats and barley) from which they can be isolated. Chemically, the backbone of the linear structure of beta-glucan polymers consists of monomers of D-glucose molecules, interconnected by specific beta-1,3 / 1,6-glycosidic bonds. Therefore, beta-glucans can be more accurately called beta-1,3 / 1,6- (D) -glucans.
In general, beta-1,3 / 1,6-glucans strengthen the body’s first “line of defense”. Namely, their main biological immunomodulatory action is based on the stimulation of the activity of innate immunity factors. Activation of macrophages is definitely a key moment in the activation of innate nonspecific immune factors. This activation is achieved by binding beta-glucans to several specific macrophage receptors.
Activated macrophages have an increased ability to detect, recognize and destroy pathogens.
In addition to stimulating phagocytosis, beta-glucans also have the ability to stimulate hematopoiesis. Increased hematopoiesis includes stimulation of leukocyte and platelet production.
Purification, ie the removal of mannoproteins and lipids from the yeast cell wall during the production process, is one of the imperatives for achieving increased bioavailability. The minimum requirements for adequate efficacy of beta glucan are considered to be the degree of purity and extraction and purification to a minimum of 70-85% beta glucan.
It is recommended to take 1 to 3 capsules a day, preferably half an hour before meals. With preventive use, it is possible to use beta glucans in adults for a longer period of time. Consult your doctor or pharmacist for an increased daily dose.
People taking medication should consult a doctor before taking it. Not recommended for pregnant and breastfeeding women.
Oleuropein is the most active medicinal compound from olive leaves responsible for the bitterness of the fruit and to which it is mainly associated with therapeutic action. The compounds present in olive leaves are generally considered to strengthen the immune system, and many scientific papers attribute various biological effects to oleuropein – antioxidant, antimicrobial, anti-inflammatory, antiviral, cytotoxic.
Scientists list as many as 126 pathological microorganisms that cannot resist the action of compounds present in olive leaf extract, many of which have already become resistant to antibiotics.
yes! In a document published in 2011 (EFSA Journal 2011; 9 (4): 2033), the European Food Safety Authority (EFSA) confirmed the effect of oleuropein and olive leaf extract on preventing the oxidation of LDL (low-density lipoprotein, so-called bad cholesterol). ) which is associated with the formation of plaques on the walls of blood vessels.
Also, today the olive leaf is one of the few herbal remedies that has been clinically tested in the treatment of hypertension.
Turmeric has a rich history in India as a spice, preservative and colorant, and has been used for centuries in the highly regarded Eastern medicine, Ayurveda where its effects are well documented as a natural remedy. The characteristic intense yellow color is defined by curcumin, an active ingredient from the group of curcuminoids, which is attributed to strong anti-inflammatory, antiviral, antibacterial and antioxidant effects. Turmeric, with its active ingredient, curcumin, has been the subject of more than 13,000 published biomedical studies that have studied the effects of curcumin on various inflammations, arthritis, various forms of cancer, neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and stroke.
At the molecular level, curcuminoids have shown the ability to inhibit nuclear kappa factor B (NF-κB), a transcription factor that induces and triggers various inflammations. NF-κB is involved in a variety of chronic diseases and conditions ranging from cardiovascular disease to cancer. Curcuminoids have significant antioxidant, antiviral, antibacterial and anti-inflammatory effects, support a healthy immune system and inhibit destructive enzymes in joints and tissues (Aggarwal B. Et al. (2006). Turmeric: The Genus Curcuma. Pp 297-368).
The most rated and clinically most tested curcumin brand on the market – more than 85 scientific publications and clinical research.
Best safety data – the only curcumin on the market that has been reviewed and recognized by the US FDA for GRAS status (Generally Recognized As Safe).
Most patented curcumin – has patents that cover the composition of curcuminoids, method of production and use.
The most consistent in quality – C3 Complex contains a continuous composition in the same proportions in each series for all 3 curcuminoids as for the black pepper extract, BioPerine®.
Multiple proven bioavailability.
Awarded for Product of the Year and Scientific Achievement by the Nutrition Business Journal (NBJ Product Merit Award; NBJ Scientific Achievement Award).
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