Beta glucans are a long-chain polysaccharide that are most commonly obtained from Saccharomyce scerevisiae yeast cells, and in nature they can be found in some edible mushrooms (reishi, maggot, shiitake, maitake), grains (oats and barley) and certain algae types.
Generally it can be said that beta glukans boost the first “defense line” of the organism. Namely, their main biological immunomodulatory action is based on stimulation of the activity of inherited immune factors.
Beta Glucan&C3 Complex Premium is a high quality product that contains:
• zinc, folic acid, vitamins B6 and B12 and vitamin C that contributes to the normal function of the immune system
• riboflavin, thiamine, niacin, biotin, pantothenic acid, vitamins B6 and B12 and vitamin C contributing to the normal energy metabolism
• zinc, riboflavin and vitamins C and E that contributes to the protection of cells from oxidative stress
• biotin, folic acid, niacin, thiamine, vitamins B6 and B12 and vitamin C that contributes to normal psychological function
• pantothenic acid that contributes to normal mental performance
• biotin, niacin, riboflavin, thiamine, vitamins B6 and B12 and vitamin C that contributes to the normal functioning of the nervous system
• zinc that contributes to normal cognitive function
|Ingredients in Recommended Daily Dose:
(children 3-6 g. and adults)
(children 6-9 g. and adults):
(children 12 g. and adults):
|Dry extract of turmeric rhizomes (Curcuma longa)
Curcumin C3 Complex®, standardized to at least 95% of curcuminoids
||20 mg||30 mg|
|Vitamin E (DL-alpha tocopheryl acetate)
||4.80 mg TE
||9.60 mg TE
||14.40 mg TE
|Vitamin C (L-ascorbic acid)
|Vitamin B1 (Tiamin mononitrate)
|Vitamin B2 (Riboflavine)
|Vitamin B6 (Pyridoxine Hydrochloride)
||0.56 mg||1.12 mg||1.68 mg|
|Pantothenic Acid (Calcium D-Pantothenate)
|Folic Acid (Pteroylmonoglutamic acid)
|Vitamin B12 (Cyanocobalamin)
|Zinc (Zinc Acetate Dihydrate)
Beta Glucans in synergy with Curcumin C3 Complex, vitamin C, folic acid, vitamin B6, B12 and zinc contribute to the normal function of the immune system.
Before each use, shake it well. It is recommended to take:
- Children from 3 to 6 years old take one spoon (= 5 mL) daily.
- Children from 7 to 12 years old take two tablespoons (= 10 mL) daily.
- Children over 12 and adults take three tablespoons (= 15 ml) daily.
The spoon is supplied in the package.
Recommended daily doses should not be exceeded. A dietary supplement is not a substitute or replacement for a balanced diet. Keep out of the reach of small children. It is important to adhere to a balanced and varied diet and a healthy lifestyle.
Before use and in case of hypersensitivity to any of the ingredients, consult a physician or pharmacist.
Store in a dry place, at temperature up to 25ºC.
It is important to maintain the normal function of the immune system as it helps the body in natural defense!
Rylander, R. Organic dust induced pulmonary disease – the role of mould derived beta-glucan. Ann.Agric.Environ.Med. 2010;17(1):9-13.3
Sable, C. A., Strohmaier, K. M., and Chodakewitz, J. A. Advances in antifungal therapy. Annu.Rev.Med. 2008;59:361-379.
Saito, T., Shime, N., Itoh, K., Fujita, N., Saito, Y., Shinozaki, M., Shibuya, K., Makimura, K., and Hashimoto, S. Disseminated aspergillosis following resolution of Pneumocystis pneumonia with sustained elevation of beta-glucan in an Intensive Care Unit: a case report. Infection 2009;37(6):547-550.
Shimizu, C., Kihara, M., Aoe, S., Araki, S., Ito, K., Hayashi, K., Watari, J., Sakata, Y., and Ikegami, S. Effect of high beta-glucan barley on serum cholesterol concentrations and visceral fat area in Japanese men–a randomized, double-blinded, placebo-controlled trial. Plant Foods Hum.Nutr. 2008;63(1):21-25.
Sier, C. F., Gelderman, K. A., Prins, F. A., and Gorter, A. Beta-glucan enhanced killing of renal cell carcinoma micrometastases by monoclonal antibody G250 directed complement activation. Int.J.Cancer 5-10-2004;109(6):900-908
Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
Theuwissen, E., Plat, J., and Mensink, R. P. Consumption of oat beta-glucan with or without plant stanols did not influence inflammatory markers in hypercholesterolemic subjects. Mol.Nutr.Food Res. 2009;53(3):370-376.
Tsikitis, V. L., Albina, J. E., and Reichner, J. S. Beta-glucan affects leukocyte navigation in a complex chemotactic gradient. Surgery 2004;136(2):384-389.
Weitberg, A. B. A phase I/II trial of beta-(1,3)/(1,6) D-glucan in the treatment of patients with advanced malignancies receiving chemotherapy. J.Exp.Clin.Cancer Res. 2008;27:40.
Wolever, T. M., Tosh, S. M., Gibbs, A. L., Brand-Miller, J., Duncan, A. M., Hart, V., Lamarche, B., Thomson, B. A., Duss, R., and Wood, P. J. Physicochemical properties of oat beta-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial. Am.J.Clin.Nutr. 2010;92(4):723-732.
Xiang, D., Sharma, V. R., Freter, C. E., and Yan, J. Anti-tumor monoclonal antibodies in conjunction with beta-glucans: a novel anti-cancer immunotherapy. Curr.Med.Chem. 2012;19(25):4298-4305.
Yan, J., Allendorf, D. J., Li, B., Yan, R., Hansen, R., and Donev, R. The role of membrane complement regulatory proteins in cancer immunotherapy. Adv.Exp.Med.Biol. 2008;632:159-174.
Yun, C. H., Estrada, A., Van Kessel, A., Park, B. C., and Laarveld, B. Beta-glucan, extracted from oat, enhances disease resistance against bacterial and parasitic infections. FEMS Immunol.Med.Microbiol. 1-21-2003;35(1):67-7
Arinaga S, Karimine N, Takamuku K, et al. Enhanced induction of lymphokine-activated killer activity after lentinan administration in patients with gastric carcinoma. Int J Immunopharmac 1992;14:535-539.
Dellinger EP, Babineau TJ, Bleicher P, et al. Effect of PGG-glucan on the rate of serious postoperative infection or death observed after high-risk gastrointestinal operations. Betafectin Gastrointestinal Study Group. Arch Surg 1999;134:977-83.
Food and Drug Administration.GRAS Notice 000239 for Yeast Beta-Glucan.Fed registr. 2003; 68: 44207-44209. (http://www.accessdata.fda.gov/scripts/fcn/gras_notices/grn000239.pdf )
Vetvička, V., B.P. Thornton, and G.D. Ross. 1996. Solubleb-glucanpolysaccharide binding to the lectin site of neutrophil or natural killer cell com-plement receptor type 3 (CD11b/CD18) generates a primed state of the recep-tor capable of mediating cytotoxicity of iC3b-opsonized target cells. J.Clin.In-vest.98:50–61.
Chan GC, Chan WK, Sze DM. The effects of beta-glucan on human immune and cancer cells. J Hematol Oncol. 2009;2:25
Jesenak M, Majtan J, Rennerova Z, Kyselovic J, Banovcin P, Hrubisko M. Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. Int Immunopharmacol. 2013;15(2):395-9.
Hunter KW, Gault RA, Berner MD. Preparation of microparticulate β-glucan from Saccharomyces cerevisiae for use in immune potentiation.Letters in Applied Microbiology. 2002: 35(4): 267-271.
Nieman DC, Henson DA, McMahon M, Wrieden JL, Davis JM, Murphy EA, Gross SJ, McAnulty LS, Dumke CL. Beta-glucan, immune function, and upper respiratory tract infections in athletes. Med Sci Sports Exerc. 2008;40(8):1463-71.
Beta-glucans are structural homopolysaccharides from cell walls of fungi and yeasts, but also grains (oats and barley) from which they can be isolated. Chemically speaking, the backbone of the linear structure of the beta-glucan polymer is made up of monomers of D-glucose molecules, interlinked with specific beta-1,3-glycosidic bonds. Therefore beta-glucans can be more precisely referred to as beta-1,3- (D) -glucans.
Generally it can be said that beta-1,3-glucans enhance the first “defense line” of the organism. Namely, their main biological immunomodulatory action is based on stimulation of the activity of inherited immune factors. Macrophage activation is definitely a crucial moment when activating factors of innate non-specific immunity. This activation is achieved by binding of beta-glucan to several specific macrophage receptors.
Activated macrophages have increased ability to detect, recognize, and destroy pathogens.
With stimulation of phagocytosis, beta-glucans have the ability to stimulate hematopoiesis. Enhanced hematopoiesis involves stimulation of leukocyte and platelet production.
- to strengthen immunity,
- In infectious conditions such as infections of the respiratory tract, infections caused by fungi, bacteria, viruses
Children aged 3 to 6 take one spoon (= 5 mL) daily.
Children 7 to 12 years of age take 2 tablespoons (= 10 mL) daily.
Children over 12 years of age and adults take three tablespoons (= 15 mL) daily.